Estructura factorial de la Brief Self-Control Scale en español / Factor structure of the Brief Self-Control Scale in Spanish

Resumen El objetivo del estudio fue explorar la estructura factorial de la Brief Self-Control Scale (BSCS; Tangney, Baumeister y Boone, 2004) aplicada como autorreporte a una muestra de 151 participantes en Colombia (edad promedio de 8.2 años, 50.33 % niñas y 49.66 % niños) y 115 participantes en Chile (edad promedio de 7.3 años, 53.04 % niñas y 49.95 % niños). La escala también fue respondida a modo de heterorreporte por 80 madres de los participantes colombianos y las 115 madres de los participantes chilenos. El Análisis Factorial Exploratorio (AFE) arrojó soluciones bifactoriales en todas las muestras y reportó valores de consistencia interna aceptables, aunque la composición de los factores difirió notablemente entre países y entre madres e hijos(as). Los hallazgos se discuten en términos de las diferencias culturales, en la socialización del autocontrol y el desarrollo de la capacidad de autorregulación en los primeros años de la escuela primaria. Se concluye que la medición del autoncontrol en este grupo etáreo mediante la BSCS requiere ajustes.

Abstract The aim of this study was to explore the factor structure of the Brief Self-Control Scale (BSCS; Tangney, Baumeister and Boone, 2004) used as self-report with a sample of 151 participants in Colombia (mean age 8.2 years, 50.33 % girls and 49.66 % boys) and 115 participants in Chile (mean age 7.3 years, 53.04 % girls and 49.95 % boys). The scale was also answered as a hetero-report by 80 mothers of the Colombian participants and the 115 mothers of the Chilean participants. The Exploratory Factor Analysis (EFA) revealed bifactor solutions in all samples and reported acceptable internal consistency values, although the composition of the factors differed markedly between countries and between mothers and children. The findings are discussed in terms of cultural differences, in the socialization self-control and development of self-regulation skills in the early elementary school years. According to these findings, the measurement of self-control in this age group using the BSCS requires adjustments.

The Role of Maternal Parenting for Children's Behavior Regulation in Environments of Risk.

This study investigates the role of maternal parenting and subjective theories for associations between environmental risk and children's behavior regulation combining a qualitative and quantitative approach. Mothers of 113 primary school children (M = 10.06, SD = 0.86) in Germany completed questionnaires on parenting, environmental risk, and their child's behavior regulation. To test for associations, we applied hierarchical regression models. Further, we conducted nine focus groups in settings of high and low environmental risk and used thematic analysis. Maternal warmth showed positive associations with children's behavior regulation. Restrictive maternal control and children's behavior regulation were related negatively. The negative association between environmental risk and children's behavior regulation was partly explained by restrictive maternal control. When maternal warmth was added into the model on environmental risk, restrictive maternal control, and children's behavior regulation, both maternal parenting practices lost its significant associations with children's behavior regulation. Qualitative findings gave insights into parents' subjective theories, suggesting adverse peer effects as possible explanation for the relation between environmental risk and children's behavior regulation. The results are discussed in terms of their contribution to theoretical considerations on behavior regulation development in different environmental risk settings.

Assessing Emotion Regulation Strategies in Chile: A Spanish Language Adaptation of the German SSKJ 3-8 Scales.

The aim of the present study is the psychometric review of a Spanish language version of the German Stress and Coping Questionnaire for Children and Adolescents (SSKJ 3-8). The SSKJ 3-8 assesses emotion regulation strategies by asking children to indicate how often they use five different emotion regulation strategies in response to a social and an academic stress situation. The Spanish language adaptation of the inventory was developed for a cross-cultural study with Chilean and German fourth-graders. The sample includes 76 German and 169 Chilean fourth graders. The SSKJ 3-8 was first translated into Spanish by a bilingual translator, then back-translated by a German native speaker, and finally adapted for the cultural context in Chile. To analyze the psychometric comparability, the measurement invariance was examined within the framework of the Item Response Theory (IRT) with the R package pairwise. The results show that the new developed Spanish language adaptation of the SSKJ 3-8 is comparable to the German version in terms of psychometric measurement characteristics. Only few items show deviations with regard to strong measurement invariance. We conclude that the Spanish language adaptation of the SSKJ 3-8 is a reliable instrument to assess emotion regulation strategies in Chile.

In vitro evaluation of 225 Ac-DOTA-substance P for targeted alpha therapy of glioblastoma multiforme.

Glioblastoma multiforme (GBM) is the most malignant form of brain tumors with dismal prognosis despite treatment by surgery combined with radiotherapy and chemotherapy. The neuropeptide Substance P (SP) is the physiological ligand of the neurokinin-1 receptor, which is highly expressed in glioblastoma cells. Thus, SP represents a potential ligand for targeted alpha therapy. In this study, a protocol for the synthesis of SP labeled with the alpha emitter 225 Ac was developed and binding affinity properties were determined. The effects of 225 Ac-DOTA-SP were investigated on human glioblastoma cell lines (T98G, U87MG, U138MG) as well as GBM stem cells. A significant dose-dependent reduction in cell viability was detected up to 6 days after treatment. Also, colony-forming capacity was inhibited at the lower doses tested. In comparison, treatment with the conventional agent temozolomide showed higher cell viability and colony-forming capacity. 225 Ac-DOTA-SP treatment caused induction of late apoptosis pathways. Cells were arrested to G2/M-phase upon treatment. Increasing doses and treatment time caused additional S-phase arrest. Similar results were obtained using human glioblastoma stem cells, known to show radioresistance. Our data suggest that 225 Ac-DOTA-SP is a promising compound for treatment of GBM.

Children's Self-Regulation in Cultural Contexts: The Role of Parental Socialization Theories, Goals, and Practices.

Self-regulation is a complex multidimensional construct which has been approached mainly in Western cultural contexts. The present contribution examines the importance of considering the culture-sensitive nature of self-regulation by reviewing theory and research on the development of children's self-regulation in different cultural contexts. This review of theory and research allows to suggest that widely shared values in a cultural group influence parental socialization theories, goals, and practices, which in turn have an impact on how children learn to self-regulate, the forms of self-regulation they develop, and the goals associated with self-regulation. Thus, this article concludes that more specific research is required to relate both the developmental and the cultural aspects of children's self-regulation.

225Ac-PSMA-617 for PSMA-Targeted α-Radiation Therapy of Metastatic Castration-Resistant Prostate Cancer.

Prostate-specific membrane antigen (PSMA) is a promising target in prostate cancer. Recently, we started the first-in-human treatment with an α-radionuclide-labeled PSMA ligand. Although the case series is still ongoing, we here report in advance about two patients in highly challenging clinical situations who showed a complete response to 225Ac-PSMA-617 therapy. METHODS: 68Ga-PSMA-11 PET/CT validated the presence of the PSMA-positive tumor phenotype. A 100-kBq activity of 225Ac-PSMA-617 per kilogram of body weight was administered bimonthly. Prostate-specific antigen response and hematologic toxicity were measured at least every 4 wk. Restaging was performed with 68Ga-PSMA-11 PET/CT. RESULTS: Both patients experienced a prostate-specific antigen decline to below the measurable level and showed a complete response on imaging. No relevant hematologic toxicity was observed. Xerostomia was the only mentionable clinical side effect. CONCLUSION: Targeted α-therapy with 225Ac-PSMA-617, although still experimental, obviously has strong potential to significantly benefit advanced-stage prostate cancer patients.

Children's Self-Regulation and School Achievement in Cultural Contexts: The Role of Maternal Restrictive Control.

Self-regulation can be developed through parent-child interactions and has been related to developmental outcomes, e.g., such as educational achievement. This study examined cross-cultural differences and similarities in maternal restrictive control, self-regulation (i.e., behavior and emotion regulation) and school achievement and relations among these variables in Germany and Chile. Seventy-six German and 167 Chilean fourth graders, their mothers, and their teachers participated. Mothers and teachers rated children's behavior regulation with a subscale of the Strengths and Difficulties Questionnaire. Children reported their use of emotion regulation strategies on the Questionnaire for the Measurement of Stress and Coping. Mothers rated maternal restrictive control by answering the Parenting Practice Questionnaire. School achievement was assessed by grades for language and mathematics. Results showed higher behavior regulation of German children in comparison to Chilean children and a higher preference of restrictive parental control in Chilean mothers than in German mothers. Regression analyses revealed positive relations between children's behavior regulation and school achievement in Germany and in Chile. Further, in both cultural contexts, maternal restrictive control was related negatively to behavior regulation and positively to anger-oriented emotion regulation. In sum, the study showed the central function of behavior regulation for school achievement underlining negative relations of maternal restrictive control with children's self-regulation and school achievement in diverse cultural contexts. Culturally adapted interventions related to parenting practices to promote children's behavior regulation may assist in also promoting children's school achievement.

Gender differences in school achievement: The role of self-regulation.

This study examined whether different aspects of self-regulation (i.e., emotion and behavior regulation) account for gender differences in German and mathematics achievement. Specifically, we investigated whether higher school achievement by girls in comparison to boys can be explained by self-regulation. German and mathematics achievement were assessed in a sample of 53 German fifth graders (19 boys, 34 girls) using formal academic performance tests (i.e., reading, writing, mathematics) and teachers' ratings (i.e., grades in German and mathematics). Moreover, teachers rated children's behavior regulation using the Self-Control Scale (SCS-K-D). Children's self-reported strategies of emotion regulation were assessed with the Questionnaire for the Measurement of Stress and Coping in Children and Adolescents (SSKJ 3-8). Age and intelligence (CFT 20-R) were included as control variables. Analyses of mean differences showed that girls outperformed boys in German achievement and behavior regulation. Regression analyses, using a bootstrapping method, revealed that relations between gender and German achievement were mediated by behavior regulation. Furthermore, we found a suppression effect of behavior regulation on the relation between gender and mathematics achievement: boys' mathematics achievement was underestimated when the analyses did not control for behavior regulation. We discuss these results from a developmental perspective and within the theoretical framework of self-regulation and achievement.

Rituximab reduces the number of peripheral blood B-cells in vitro mainly by effector cell-mediated mechanisms.

BACKGROUND AND OBJECTIVES: The humanized CD20 mono- clonal antibody, rituximab, has significant anti-tumor activity in patients with B-cell non-Hodgkin's lymphoma and induces depletion of B-cells in vivo. It was the objective of this study to define the contribution of the different mechanisms of action of rituximab on primary normal and malignant B-cells. DESIGN AND METHODS: Primary human B-lymphocytes and effector cell fractions were isolated from peripheral blood of normal donors using an immunomagnetic separation technique. Blood samples from 20 patients with chronic lymphocytic leukemia (CLL) were studied and the B-lymphoblastoid Daudi cell line was used as a control. B-cells were cultured in the presence or absence of rituximab adding a secondary hyper-crosslinking antibody, serum as source of complement or different effector cell fractions. The cells were analyzed by immunofluorescence staining and flow cytometry. RESULTS: In contrast to the B-lymphoblastoid Daudi cell line, the number of highly purified normal peripheral blood CD19+ cells was only minimally affected by rituximab in the presence of autologous serum. A significant reduction in the number of B-cells was observed when mononuclear cells from peripheral blood were added back. To identify the cell type which mediates this effect, CD3+ T-cells, CD56+ cells, and CD14+ monocytes were added to selected CD22+ B-cells. A marked B-cell decrease was only observed in the presence of CD56+ and CD14+ cells in an effector to target ratio of 10:1. The experiments with mononuclear cells from patients with CLL showed a B-cell reduction by rituximab, which was significantly enhanced following addition of granulocyte-macrophage colony-stimulating factor (GM-CSF). INTERPRETATION AND CONCLUSIONS: These data support the important role of cell-mediated mechanisms in the B-cell-depleting action of rituximab and suggest that pre-treatment with GM-CSF could improve the response to rituximab in patients with CLL.